List of UK Independent Singles Chart number ones of 2016
These are the Official Charts Company's UK Independent Singles Chart number-one singles of 2016.
Chart history
| Chart date | Song | Artist | Record label | References |
| 7 January | "Hello" | Adele | XL | |
| 14 January | "Hello" | Adele | XL | |
| 21 January | "Sweet Lovin" | Sigala featuring Bryn Christopher | Ministry of Sound | |
| 28 January | "Hello" | Adele | XL | |
| 4 February | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 11 February | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 18 February | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 25 February | "Swings & Waterslides" | Viola Beach | Fuller Beans | |
| 3 March | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 10 March | "When We Were Young" | Adele | XL | |
| 17 March | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 24 March | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 31 March | "Say You Do" | Sigala featuring DJ Fresh and Imani Williams | Ministry Of Sound | |
| 7 April | "Say You Do" | Sigala featuring DJ Fresh and Imani Williams | Ministry Of Sound | |
| 14 April | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 21 April | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 28 April | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 5 May | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 12 May | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 19 May | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 26 May | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 2 June | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 9 June | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | |
| 16 June | "Send My Love (To Your New Lover)" | Adele | XL | |
| 23 June | "I'll Be There" | The Neales | ZY | |
| 30 June | "Give Me Your Love" | Sigala featuring John Newman and Nile Rodgers | Ministry of Sound | |
| 7 July | "Send My Love " | Adele | XL | |
| 14 July | "Send My Love " | Adele | XL | |
| 21 July | "Send My Love " | Adele | XL | |
| 28 July | "Send My Love " | Adele | XL | |
| 4 August | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 11 August | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 18 August | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 25 August | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 1 September | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 8 September | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 15 September | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 22 September | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 29 September | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 6 October | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 13 October | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 20 October | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 27 October | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 3 November | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 10 November | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 17 November | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 24 November | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 1 December | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 8 December | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 15 December | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 22 December | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | Because Music | |
| 29 December | "Glad All Over" | The Dave Clark Five | Dave Clark |