| Team | First
season | Last
season | Location | Fate |
| Asheville Orioles | 1972 | 1975 | Asheville, North Carolina | Relocated to Charlotte, North Carolina, as the Charlotte O's |
| Asheville Tourists | 1964 | 1971 | Asheville, North Carolina | Renamed the Asheville Orioles |
| Biloxi Shuckers | 2015 | – | Biloxi, Mississippi | Active |
| Birmingham A's | 1967 | 1975 | Birmingham, Alabama | Relocated to Chattanooga, Tennessee, as the Chattanooga Lookouts |
| Birmingham Barons | 1964 | 1965 | Birmingham, Alabama | Renamed the Birmingham A's in 1967 |
| Birmingham Barons | 1981 | – | Birmingham, Alabama | Active |
| Carolina Mudcats | 1991 | 2011 | Zebulon, North Carolina | Relocated to Pensacola, Florida, as the Pensacola Blue Wahoos |
| Charlotte Hornets | 1964 | 1972 | Charlotte, North Carolina | Folded |
| Charlotte Knights | 1988 | 1992 | Charlotte, North Carolina | Transferred to the International League |
| Charlotte O's | 1976 | 1987 | Charlotte, North Carolina | Renamed the Charlotte Knights |
| Chattanooga Lookouts | 1964 | 1965 | Chattanooga, Tennessee | Folded |
| Chattanooga Lookouts | 1976 | – | Chattanooga, Tennessee | Active |
| Columbus Astros | 1970 | 1988 | Columbus, Georgia | Renamed the Columbus Mudcats |
| Columbus Clingstones | 2025 | – | Columbus, Georgia | Active |
| Columbus Confederate Yankees | 1964 | 1966 | Columbus, Georgia | Folded |
| Columbus Mudcats | 1989 | 1990 | Columbus, Georgia | Relocated to Zebulon, North Carolina, as the Carolina Mudcats |
| Columbus White Sox | 1969 | 1969 | Columbus, Georgia | Renamed the Columbus Astros |
| Evansville White Sox | 1966 | 1968 | Evansville, Indiana | Folded |
| Greenville Braves | 1984 | 2004 | Greenville, South Carolina | Relocated to Pearl, Mississippi, as the Mississippi Braves |
| Huntsville Stars | 1985 | 2014 | Huntsville, Alabama | Relocated to Biloxi, Mississippi, as the Biloxi Shuckers |
| Jackson Generals | 2011 | 2020 | Jackson, Tennessee | Folded |
| Jacksonville Expos | 1985 | 1990 | Jacksonville, Florida | Renamed the Jacksonville Suns |
| Jacksonville Jumbo Shrimp | 2017 | 2020 | Jacksonville, Florida | Transferred to the International League |
| Jacksonville Suns | 1970 | 2016 | Jacksonville, Florida | Renamed the Jacksonville Jumbo Shrimp |
| Knoxville Blue Jays | 1980 | 1992 | Knoxville, Tennessee | Renamed the Knoxville Smokies |
| Knoxville Smokies | 1964 | 1967 | Knoxville, Tennessee | Folded |
| Knoxville Smokies | 1993 | 1999 | Knoxville, Tennessee | Relocated to Kodak, Tennessee, as the Tennessee Smokies |
| Knoxville Smokies | 2025 | – | Knoxville, Tennessee | Active |
| Knoxville Sox | 1972 | 1979 | Knoxville, Tennessee | Renamed the Knoxville Blue Jays |
| Lynchburg White Sox | 1964 | 1965 | Lynchburg, Virginia | Transferred to the Carolina League |
| Macon Peaches | 1964 | 1967 | Macon, Georgia | Folded |
| Memphis Chicks | 1978 | 1997 | Memphis, Tennessee | Relocated to Jackson, Tennessee, as the West Tenn Diamond Jaxx |
| Mississippi Braves | 2005 | 2024 | Pearl, Mississippi | Relocated to Columbus, Georgia, as the Columbus Clingstones |
| Mobile Athletics | 1966 | 1966 | Mobile, Alabama | Folded |
| Mobile BayBears | 1997 | 2019 | Mobile, Alabama | Relocated to Madison, Alabama, as the Rocket City Trash Pandas |
| Mobile White Sox | 1970 | 1970 | Mobile, Alabama | Folded |
| Montgomery Biscuits | 2004 | – | Montgomery, Alabama | Active |
| Montgomery Rebels | 1965 | 1980 | Montgomery, Alabama | Relocated to Birmingham, Alabama, as the Birmingham Barons |
| Nashville Sounds | 1978 | 1984 | Nashville, Tennessee | Relocated to Huntsville, Alabama, as the Huntsville Stars |
| Nashville Xpress | 1993 | 1994 | Nashville, Tennessee | Relocated to Wilmington, North Carolina, as the Port City Roosters |
| Orlando Cubs | 1993 | 1996 | Orlando, Florida | Renamed the Orlando Rays |
| Orlando Rays | 1997 | 2003 | Orlando, Florida | Relocated to Montgomery, Alabama, as the Montgomery Biscuits |
| Orlando Sun Rays | 1990 | 1992 | Orlando, Florida | Renamed the Orlando Cubs |
| Orlando Twins | 1973 | 1989 | Orlando, Florida | Renamed the Orlando Sun Rays |
| Pensacola Blue Wahoos | 2012 | – | Pensacola, Florida | Active |
| Port City Roosters | 1995 | 1996 | Wilmington, North Carolina | Relocated to Mobile, Alabama, as the Mobile BayBears |
| Rocket City Trash Pandas | 2020 | – | Madison, Alabama | Active |
| Savannah Braves | 1971 | 1983 | Savannah, Georgia | Relocated to Greenville, South Carolina, as the Greenville Braves |
| Savannah Indians | 1970 | 1970 | Savannah, Georgia | Renamed the Savannah Braves |
| Savannah Senators | 1968 | 1969 | Savannah, Georgia | Renamed the Savannah Indians |
| Tennessee Smokies | 2000 | 2024 | Kodak, Tennessee | Relocated to Knoxville, Tennessee, as the Knoxville Smokies |
| West Tenn Diamond Jaxx | 1998 | 2010 | Jackson, Tennessee | Renamed the Jackson Generals |