List of Serie A hat-tricks
Since the inception of the Italian football league competition, the Serie A, in 1929, more than 250 players have scored three goals or more in a single match. Swedish striker Gunnar Nordahl holds the record for most Serie A hat-tricks, having scored seventeen from 1949 to 1955. He scored all his hat-tricks while representing Milan, making him the player with most hat-tricks for a single club. He is followed by Italian striker Giuseppe Meazza who scored fifteen hat-tricks, all of them with Internazionale. Kurt Hamrin and István Nyers are in third place, with twelve hat-tricks each.
Over fifty players have scored more than three goals in a single match; of these, eleven players, Carlo Galli, Kurt Hamrin, Miroslav Klose, Roberto Pruzzo, Bruno Ispiro, István Mike Mayer, Antonio Angelillo, Giuseppe Meazza, Cesare Fasanelli, Emanuele Del Vecchio and Giovanni Vecchina have scored five. Silvio Piola and Omar Sívori have scored the most goals in a single match at six goals each. Gunnar Nordahl, Giuseppe Meazza and Kurt Hamrin have scored four or more goals three times in Serie A, more than any other player.
Serie A all-time top goalscorer Silvio Piola holds the record as the youngest player to score a hat-trick, and the youngest to score more than three goals in one match. Rodrigo Palacio is the oldest player to score a hat-trick.
Hat-tricks
Multiple hat-tricks
The following table lists the minimum number of hat-tricks scored by players who have scored two or more hat-tricks.Players in bold are still active in Serie A. Players in italics are still active outside the Serie A.
| Rank | Player | Hat-tricks | Last hat-trick |
| 1 |  |