| Name | | System | From | To | Successor | Notes |
| Asbestos and Danville Railway | ASDA | | 1897 | | | - |
| Atlantic and Lake Superior Railway | | | 1893 | 1907 | Quebec Oriental Railway | - |
| Atlantic and North-West Railway | | CP | 1879 | | | Still exists as a nonoperating subsidiary of the Canadian Pacific Railway |
| Atlantic, Quebec and Western Railway | | | 1901 | 1929 | Canadian National Railway | - |
| Baie des Chaleurs Railway | | | 1882 | 1894 | Atlantic and Lake Superior Railway | - |
| Beauharnois Junction Railway | | GT | 1873 | 1893 | Grand Trunk Railway | - |
| Boston, Concord and Montreal Railroad | | B&M | 1875 | 1878 | South Eastern Railway | - |
| Boston and Lowell Railroad | | B&M | 1887 | 1887 | Boston and Maine Railroad | - |
| Boston and Maine Railroad | B&M | B&M | 1887 | 1926 | Canadian Pacific Railway, Quebec Central Railway | - |
| Canada Atlantic Railway | | GT | 1879 | 1914 | Grand Trunk Railway | - |
| Canada and Gulf Terminal Railway | CGT | | 1909 | | | Still exists as a lessor of Canadian National Railway subsidiary Matapedia and Gulf Railway |
| Canadian American Railroad | CDAC | | 1995 | 2003 | Montreal, Maine and Atlantic Railway | - |
| Canadian Atlantic Railway | | CP | 1988 | 1994 | Canadian American Railroad | - |
| Canadian Government Railways | CGR | CGR | 1915 | 1993 | Canadian National Railway | - |
| Canadian Northern Montreal Tunnel and Terminal Company | | CNor | 1911 | 1914 | Mount Royal Tunnel and Terminal Company | - |
| Canadian Northern Quebec Railway | CNQ | CNor | 1906 | | | Still exists as a subsidiary of the Canadian National Railway |
| Cap de la Madeleine Railway | | CP | 1895 | | | - |
| Carillon and Grenville Railway | | CNor | 1859 | 1914 | Canadian Northern Quebec Railway | - |
| Central Railway of Canada | | | 1905 | | | - |
| Central Vermont Railroad | | GT | 1873 | 1899 | Central Vermont Railway | - |
| Central Vermont Railway | CV | GT | 1899 | 1956 | Canadian National Railway | - |
| Champlain and St. Lawrence Railroad | | GT | 1832 | 1857 | Montreal and Champlain Railroad | - |
| Chateauguay and Northern Railway | | CNor | 1895 | 1906 | Canadian Northern Quebec Railway | - |
| Connecticut and Passumpsic Rivers Railroad | | B&M | 1870 | 1887 | Boston and Lowell Railroad | - |
| Consolidated Rail Corporation | CR | | 1976 | 1999 | CSX Transportation | - |
| Coteau and Province Line Railway and Bridge Company | | GT | 1872 | 1879 | Canada Atlantic Railway | - |
| Dessaulles Wooden Railway | | | 1850 | c.1861 | | Connected limestone quarries in St. Dominique, QC, to the Grand Trunk Railway at Britannia Mills. |
| Dominion Timber and Minerals Railway | | | 1916 | 1981 | | Also known as the Canadian Refractories Railway |
| Drummond County Railway | | CGR | 1886 | 1899 | Intercolonial Railway | - |
| East Richelieu Valley Railway | | D&H | 1890 | 1900 | Quebec Southern Railway | - |
| Grand Trunk Railway | GT | GT | 1852 | 1923 | Canadian National Railway | |
| Great Eastern Railway | | | 1882 | 1894 | Atlantic and Lake Superior Railway | - |
| Great Northern Railway of Canada | | CNor | 1883 | 1906 | Canadian Northern Quebec Railway | - |
| Hereford Railway | | MEC | 1888 | 1928 | Canadian Pacific Railway | |
| Hereford Branch Railway | | MEC | 1887 | 1888 | Hereford Railway | |
| Intercolonial Railway | IRC | CGR | 1867 | 1993 | Canadian National Railway | - |
| International Railway | | CP | 1877 | 1886 | Atlantic and North-West Railway | - |
| Jacques Cartier Union Railway | | GT | 1880 | 1893 | Grand Trunk Railway | - |
| Joliette and Brandon Railway | | CP | 1905 | 1962 | Canadian Pacific Railway | The section from St-Félix-de-Valois to St-Gabriel-de-Brandon was abandoned in 1983. The section from St-Félix-de-Valois to Joliette was sold by the Canadian Pacific Railway to the Chemin de fer Lanaudière in 1992. |
| Joliette Railway Company | | CP | 1905 | 1962 | Canadian Pacific Railway | The section from the village of Lanoraie to Joliette Jcn was abandoned in 1881. The remaining section from Joliette Jcn to the city of Joliette was sold by the Canadian Pacific Railway to the Chemin de fer Lanaudière in 1992. In 1997, it was acquired by the Quebec Gatineau Railway which is owned by Genesee & Wyoming Railroads Inc. |
| Lake Champlain and St. Lawrence Junction Railway | | CP | 1875 | | | Still exists as a nonoperating subsidiary of the Canadian Pacific Railway |
| Lake St. Louis and Province Line Railway | | GT | 1847 | 1850 | Montreal and New York Railroad | - |
| Lake Temiscamingue Colonization Railway | | CP | 1886 | | | - |
| L'Epiphanie & L'Assomption Railway | | | 1886 | 1903 | abandoned | - |
| Levis and Kennebec Railway | | CP | 1869 | 1881 | Quebec Central Railway | - |
| Lotbinière and Megantic Railway | | CGR | 1889 | 1920 | Canadian Government Railways | - |
| Lower Laurentian Railway | | CNor | 1888 | 1900 | Great Northern Railway of Canada | - |
| Maine Central Railroad | | MEC | 1890 | 1925 | N/A | |
| Massawippi Valley Railway | | B&M | 1862 | | | Still exists as a nonoperating subsidiary of the Canadian Pacific Railway |
| Matane and Gaspé Railway | | | 1902 | 1909 | Canada and Gulf Terminal Railway | - |
| Matapedia Railway | | | 1997 | 1999 | Matapedia and Gulf Railway | - |
| Missisquoi and Black Rivers Valley Railway | | CP | 1870 | 1881 | Missisquoi Valley Railway | - |
| Missisquoi and Clyde Rivers Railroad | | CP | 1869 | 1880 | Newport and Richford Railroad | - |
| Missisquoi Valley Railway | | CP | 1881 | | | Still exists as a nonoperating subsidiary of the Canadian Pacific Railway |
| Montfort Colonization Railway | | CNor | 1890 | 1898 | Montfort and Gatineau Colonization Railway | - |
| Montfort and Gatineau Colonization Railway | | CNor | 1898 | 1902 | Great Northern Railway of Canada | - |
| Montreal and Atlantic Railway | | CP | 1891 | | | Still exists as a nonoperating subsidiary of the Canadian Pacific Railway |
| Montreal and Bytown Railway | | CNor | 1853 | 1859 | Carillon and Grenville Railway | - |
| Montreal, Chambly and Sorel Railway | | GT | 1871 | 1875 | Montreal, Portland and Boston Railway | - |
| Montreal and Champlain Railroad | | GT | 1857 | 1872 | Grand Trunk Railway | - |
| Montreal and Champlain Junction Railway | | GT | 1870 | 1893 | Grand Trunk Railway | - |
| Montreal and [City of Ottawa Junction Railway] | | GT | 1871 | 1879 | Canada Atlantic Railway | - |
| Montreal and Lachine Railroad | | GT | 1846 | 1850 | Montreal and New York Railroad | - |
| Montreal and Lake Maskinonge Railway | | CP | 1887 | 1905 | Joliette and Brandon Railway | - |
| Montreal and New York Railroad | | GT | 1850 | 1857 | Montreal and Champlain Railroad | - |
| Montreal Northern Colonization Railway | | CP | 1869 | 1875 | Montreal, Ottawa and Western Railway, Quebec, Montreal, Ottawa and Occidental Railway | - |
| Montreal and Ottawa Railway | | CP | 1890 | 1958 | Canadian Pacific Railway | - |
| Montreal, Ottawa and Western Railway | | CP | 1875 | 1883 | Montreal and Western Railway | - |
| Montreal, Portland and Boston Railway | | GT | 1875 | 1896 | Montreal and Province Line Railway | - |
| Montreal and Province Line Railway | | GT | 1896 | | | - |
| Montreal and Sorel Railway | | D&H | 1881 | 1894 | South Shore Railway | - |
| Montreal and Southern Counties Railway | | GT | 1897 | 1957 | Canadian National Railway | Electric until 1956 |
| Montreal and Vermont Junction Railway | | GT | 1849 | 1956 | Canadian National Railway | - |
| Montreal and Western Railway | | CP | 1883 | | Canadian Pacific Railway | - |
| Mount Royal Tunnel and Terminal Company | | CNor | 1914 | | | - |
| Napierville Junction Railway | NJ | D&H | 1888 | | | Still exists as a subsidiary of the Canadian Pacific Railway |
| National Transcontinental Railway | | CGR | 1903 | 1993 | Canadian National Railway | - |
| National Transcontinental Railway Branch Line Company | | CN | 1926 | 1954 | Canadian National Railways | Closed in 1979 and dismantled in 1981. |
| New York Central Railroad | NYC | NYC | 1914 | 1968 | Penn Central Transportation Company | - |
| New York Central and Hudson River Railroad | | NYC | 1898 | 1914 | New York Central Railroad | - |
| Newport and Richford Railroad | | CP | 1880 | 2003 | Montreal, Maine and Atlantic Railway | - |
| North Shore Railway | | CP | 1882 | 1885 | Canadian Pacific Railway | - |
| North Shore Railway | | CP | 1870 | 1875 | Quebec, Montreal, Ottawa and Occidental Railway | - |
| North Shore Railway | | CP | 1853 | 1858 | North Shore Railway and St. Maurice Navigation Company | - |
| North Shore Railway and St. Maurice Navigation Company | | CP | 1858 | 1858 | North Shore Railway and St. Maurice Navigation and Land Company | - |
| North Shore Railway and St. Maurice Navigation and Land Company | | CP | 1858 | 1870 | North Shore Railway | - |
| Northern Colonization Railway | | | 1899 | 1956 | Canadian Pacific Railway | - |
| Ontario and Quebec Railway | | CP | 1871 | 1998 | St. Lawrence and Hudson Railway | - |
| Orford Mountain Railway | | CP | 1888 | 1958 | Canadian Pacific Railway | - |
| Ottawa and Gatineau Railway | | CP | 1894 | 1901 | Ottawa, Northern and Western Railway | - |
| Ottawa and Gatineau Valley Railway | | CP | 1871 | 1894 | Ottawa and Gatineau Railway | - |
| Ottawa Interprovincial Bridge Company | | CP | 1898 | | | - |
| Ottawa, Northern and Western Railway | | CP | 1901 | 1958 | Canadian Pacific Railway | - |
| Ottawa River Railway | | | 1903 | 1905 | Central Railway of Canada | - |
| Ottawa Valley Railway | | | 1892 | 1894 | Atlantic and Lake Superior Railway | - |
| Penn Central Transportation Company | PC | | 1968 | 1976 | Consolidated Rail Corporation | - |
| Philipsburg Railway and Quarry Company | | | 1895 | | | - |
| Philipsburg, Farnham and Yamaska Railway | | CP | 1871 | 1875 | Lake Champlain and St. Lawrence Junction Railway | - |
| Philipsburg Junction Railway and Quarry Company | | | 1888 | 1895 | Philipsburg Railway and Quarry Company | - |
| Pontiac Pacific Junction Railway | | CP | 1880 | 1903 | Ottawa, Northern and Western Railway | - |
| Pontiac and Renfrew Railway | | | 1888 | 1894 | N/A | - |
| Quebec Railway, Light and Power Company | QL&P, QLP | | 1899 | 1951 | Canadian National Railway | Electric until 1959 |
| Quebec Bridge Company | | CGR | 1887 | 1903 | Quebec Bridge and Railway Company | - |
| Quebec Bridge and Railway Company | | CGR | 1903 | | | - |
| Quebec Central Railway | QC | CP | 1875 | 2006 | N/A | - |
| Quebec and Gosford Railway | Q&GR | | 1868 | 1873 | Quebec and Lake St. John Railway | - |
| Quebec and James Bay Railway | | CNor | 1883 | 1897 | Great Northern Railway of Canada | - |
| Quebec and Lake St. John Railway | Q&LS | CNor | 1869 | | | Still exists as a subsidiary of the Canadian National Railway |
| Quebec, Montmorency and Charlevoix Railway | | | 1881 | 1899 | Quebec Railway, Light and Power Company | - |
| Quebec, Montreal, Ottawa and Occidental Railway | | CP | 1875 | 1882 | Canadian Pacific Railway, North Shore Railway | - |
| Quebec, Montreal and Southern Railway | QM&S | D&H | 1906 | 1929 | Canadian National Railway | - |
| Quebec, New Brunswick and Nova Scotia Railway | | CNor | 1903 | 1906 | Canadian Northern Quebec Railway | - |
| Quebec Oriental Railway | | | 1903 | 1929 | Canadian National Railway | - |
| Quebec and Richmond Railway | | GT | 1850 | 1853 | Grand Trunk Railway | - |
| Quebec and Saguenay Railway | | CGR | 1905 | 1919 | Canadian Government Railways | - |
| Quebec Southern Railway | QSR | | 1996 | 2003 | Montreal, Maine and Atlantic Railway | - |
| Quebec Southern Railway | | D&H | 1900 | 1906 | Quebec, Montreal and Southern Railway | - |
| Quebec and Western Railway | | CP | 1924 | | | Still exists as a subsidiary of the Canadian Pacific Railway |
| Richelieu, Drummond and Arthabaska Counties Railway | RD&ACRW | CP | 1869 | 1872 | South Eastern Railway | - |
| Rouyn Mines Railway | | CN | 1925 | 1926 | National Transcontinental Railway Branch Line Company | - |
| Rutland Railroad | R, RUT | R | 1901 | 1934 | N/A | - |
| Rutland and Noyan Railway | | R | 1899 | 1934 | N/A | A very short railroad of some 6 km, between a point on the US Border north of Alburgh VT and Noyan QC. |
| St. Francis and Megantic International Railway | | CP | 1870 | 1877 | International Railway | - |
| St. Lawrence and Adirondack Railway | | NYC | 1888 | | | Still exists as a nonoperating subsidiary of CSX Transportation |
| St. Lawrence and Atlantic Railroad | | GT | 1845 | 1853 | Grand Trunk Railway | |
| St. Lawrence and Hudson Railway | STLH | CP | 1996 | 2001 | Canadian Pacific Railway | - |
| St. Lawrence, Lower Laurentian and Saguenay Railway | | CNor | 1878 | 1888 | Lower Laurentian Railway | - |
| St. Lawrence and Industry Village Railway | | CP | 1847 | 1879 | Joliette Railway Company | - |
| St. Maurice Railway and Navigation Company | | CP | 1857 | 1858 | North Shore Railway and St. Maurice Navigation Company | - |
| St. Maurice Valley Railway | | CP | 1904 | 1958 | Canadian Pacific Railway | - |
| Shawinigan Falls Terminal Railway | | | 1902 | | | Electric until the 1950s; still exists as a joint subsidiary of the Canadian National Railway and Canadian Pacific Railway |
| Sherbrooke, Eastern Townships and Kennebec Railway | | CP | 1869 | 1875 | Quebec Central Railway | - |
| South Shore Railway | | D&H | 1894 | 1902 | Quebec Southern Railway | - |
| South Eastern Railway | | CP | 1872 | 1891 | Montreal and Atlantic Railway | - |
| South Eastern Counties Junction Railway | | CP | 1866 | 1872 | South Eastern Railway | - |
| Southwestern Railway | | NYC | 1888 | 1896 | St. Lawrence and Adirondack Railway | - |
| Stanstead, Shefford and Chambly Railroad | | GT | 1853 | 1956 | Canadian National Railway | - |
| Temiscouata Railway | TMC | | 1885 | 1949 | Canadian National Railway | - |
| Trans-Ontario Railway | TOR | | 1996 | 1997 | Ottawa Valley Railway | - |
| United Counties Railway | | D&H | 1883 | 1900 | Quebec Southern Railway | - |
| Vaudreuil and Prescott Railway | | CP | 1884 | 1890 | Montreal and Ottawa Railway | - |
| Vermont Central Railroad | | GT | | 1873 | Central Vermont Railroad | - |
| Waterloo and Magog Railway | | CP | 1871 | 1888 | Atlantic and North-West Railway | - |