List of American films of 2000
This is a list of American films released in 2000.
Box office
The highest-grossing American films released in 2000, by domestic box office gross revenue, are as follows:| Rank | Title | Distributor | Domestic gross |
| 1 | How the Grinch Stole Christmas | Universal Pictures | $260,745,620 |
| 2 | Cast Away | 20th Century Fox | $233,632,142 |
| 3 | Mission: Impossible 2 | Paramount Pictures | $215,409,889 |
| 4 | Gladiator | DreamWorks Distribution | $187,705,427 |
| 5 | What Women Want | Paramount Pictures | $182,811,707 |
| 6 | The Perfect Storm | Warner Bros. Pictures | $182,618,434 |
| 7 | Meet the Parents | Universal Pictures | $166,244,045 |
| 8 | X-Men | 20th Century Fox | $157,299,718 |
| 9 | Scary Movie | Miramax | $157,019,771 |
| 10 | What Lies Beneath | DreamWorks Distribution | $155,464,351 |