| # | Date | Film | Gross | Notes |
| 1 | | National Treasure: Book of Secrets | $123,862 | |
| 2 | | Enchanted | $107,061 | |
| 3 | | I Am Legend | $312,762 | |
| 4 | | I Am Legend | $154,075 | |
| 5 | | I Am Legend | $115,174 | |
| 6 | | Cloverfield | $95,123 | |
| 7 | | The Water Horse: Legend of the Deep | $93,698 | |
| 8 | | The Water Horse: Legend of the Deep | $70,187 | |
| 9 | | American Gangster | $80,601 | |
| 10 | | 10,000 BC | $309,515 | |
| 11 | | 10,000 BC | $224,902 | |
| 12 | | 10,000 BC | $156,789 | |
| 13 | | 31 minutos † | $286,427 | |
| 14 | | 31 minutos † | $220,985 | |
| 15 | | 31 minutos † | $121,552 | |
| 16 | | 31 minutos † | $106,283 | |
| 17 | | 31 minutos † | $72,801 | |
| 18 | | Iron Man | $527,314 | |
| 19 | | Iron Man | $185,4051 | |
| 20 | | The Chronicles of Narnia: Prince Caspian | $539,888 | |
| 21 | | Indiana Jones and the Kingdom of the Crystal Skull | $483,914 | |
| 22 | | Indiana Jones and the Kingdom of the Crystal Skull | $296,499 | |
| 23 | | The Chronicles of Narnia: Prince Caspian | $209,544 | |
| 24 | | The Happening | $223,054 | |
| 25 | | Get Smart | $192,453 | |
| 26 | | Wall-E | $545,035 | |
| 27 | | Wall-E | $435,033 | |
| 28 | | Kung Fu Panda | $508,559 | |
| 29 | | The Dark Knight | $805,318 | |
| 30 | | The Dark Knight | $604,025 | |
| 31 | | The Mummy: Tomb of the Dragon Emperor | $443,260 | |
| 32 | | Journey to the Center of the Earth | $319,620 | |
| 33 | | Journey to the Center of the Earth | $305,775 | |
| 34 | | Journey to the Center of the Earth | $151,955 | |
| 35 | | Journey to the Center of the Earth | $149,051 | |
| 36 | | Journey to the Center of the Earth | $114,406 | |
| 37 | | You Don't Mess with the Zohan | $114,298 | |
| 38 | | Journey to the Center of the Earth | $89,661 | |
| 39 | | Journey to the Center of the Earth | $81,495 | |
| 40 | | Mirrors | $83,802 | |
| 41 | | Mirrors | $64,361 | |
| 42 | | Mamma Mia! | $92,675 | |
| 43 | | Mamma Mia! | $47,239 | |
| 44 | | Mamma Mia! | $63,630 | |
| 45 | | Quantum of Solace | $259,998 | |
| 46 | | Quantum of Solace | $154,842 | |
| 47 | | High School Musical 3: Senior Year | $226,153 | High School Musical 3: Senior Year is the highest weekend opening for a musical film. |
| 48 | | High School Musical 3: Senior Year | $115,978 | |
| 49 | | Madagascar: Escape 2 Africa | $402,766 | |
| 50 | | The Day the Earth Stood Still | $243,095 | |
| 51 | | Madagascar: Escape 2 Africa | $178,780 | |
| 52 | | Bolt | $269,313 | |