| Name | Notability | References | - |
| Edward Clifford Anderson Sr. | Mayor of Savannah for eight terms before and after the American Civil War, 15-year veteran of the U.S. Navy, and brigadier general in the Confederate States Army. Led Savannah's Reconstruction efforts. | | - |
| George Wayne Anderson Jr. | Commander of Fort McAllister during American Civil War, member of the Republican Blues. Born at, and later owned, the Lebanon plantation located between Fort McAllister and Savannah. | | - |
| Francis S. Bartow | Confederate politician and Confederate States Army officer during the American Civil War | | - |
| John M. Berrien | U.S. senator from the state of Georgia | | - |
| William Bellinger Bulloch | U.S. senator from Georgia and relative of U.S. president Theodore Roosevelt | | - |
| Robert Milledge Charlton | U.S. senator representing Georgia | | - |
| Isaiah Davenport | Master builder; constructed what is now known as the Isaiah Davenport House in 1820 | | - |
| Stephen Elliott | 37th bishop of the Episcopal Church in the United States of America | | - |
| William Bennett Fleming | U.S. representative from Georgia | | - |
| Jeremy F. Gilmer | Chief of engineers for the Confederate States Army during the American Civil War | | - |
| William Washington Gordon | Politician and businessman, co-founded and served as first president of the Central Railroad and Banking Company | | - |
| Delia Green | Child murder victim and inspiration for the song "Delia's Gone", initially buried in an unmarked grave. In 2020 the Killer Blues Headstone Project placed a headstone for her at that location. | | |
| Simon Guckenheimer | Merchant | | - |
| Alfred Haywood | Merchant and city councillor | | - |
| W. W. Law | American civil rights leader and president of the Savannah NAACP, who established many African American cultural institutions in Savannah, Georgia. | | - |
| Juliette Gordon Low | Founder of the Girl Scouts of the USA | | - |
| George Paul Harrison, Sr. | Brigadier general and colonel in the Georgia militia; member of the Georgia House of Representatives | | - |
| Julian Hartridge | U.S. representative from Georgia | | - |
| Mary Haskell | Educator | | - |
| Frank O'Driscoll Hunter | World War I fighter ace and the recipient of Distinguished Service Cross five times. Later served as commanding general of the VIII Fighter Command and, later the First Air Force, during World War II | | - |
| Florence Martus | Nicknamed "the Waving Girl", the unofficial greeter of all ships entering and leaving the Port of Savannah from 1887 to 1931 | | - |
| Lucy Barrow McIntire | Activist, preservationist, actor, and poet | | - |
| Lafayette McLaws | U.S. Army officer and a Confederate general in the American Civil War | | - |
| Isaac P. Mendes | Rabbi | | - |
| John Millen | U.S. representative and lawyer from Georgia | | - |
| Thomas Manson Norwood | U.S. senator and U.S. representative from Georgia | | - |
| George Welshman Owens | U.S. representative and lawyer from Georgia | | - |
| James Lord Pierpont | Writer and composer of the song "Jingle Bells" | | - |
| John William Pearson | Businessman and Confederate captain of the Oklawaha Rangers | | - |
| Phoebe Pember | Confederate nurse at Chimborazo Hospital in Richmond, Virginia, during the American Civil War | | - |
| Philip Phillips | Lawyer, politician and U.S. representative from Alabama | | - |
| Anna Davenport Raines | Founding Vice President of the United Daughters of the Confederacy | | - |
| James C. Saltus | Confederate States Army officer, carpenter; oversaw the construction of the third City Market building | | - |
| Augustus Schwaab | Architect | | - |
| Ephraim Scudder | Builder, prominent in the antebellum form around Savannah | - | - |
| Moxley Sorrel | Confederate States Army officer and historian of the Confederacy | | - |
| William Henry Stiles | U.S. representative from Georgia. | | - |
| James Johnston Waring | Physician | | - |
| Joseph Wasden | Confederate officer in the American Civil War | | - |
| James Moore Wayne | Associate justice of the Supreme Court of the United States and a U.S. representative from Georgia | | - |
| Richard Wayne | Mayor of Savannah for four terms | | - |