LU domain
The LU domain is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.
A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved LU domain of about 100 amino-acid residues. Among these proteins, most contain only a single LU domain, though small numbers of exceptions are known; well-studied family member uPAR has three tandem LU domains.
Structure
This domain folds into five antiparallel beta sheets, a structure common to the three-finger protein family. The domain typically contains ten well-conserved cysteine residues involved in five disulfide bonds, though some examples such as two of the three uPAR domains have fewer.Examples
Besides uPAR, other receptors with LU domains include members of the transforming growth factor beta receptor superfamily, such as the activin type 2 receptor; and bone morphogenetic [protein receptor, type IA]. Other LU domain proteins are small globular proteins such as CD59 antigen, LYNX1, SLURP1, and SLURP2.Subfamilies
Human proteins containing this domain
ARS; CD177; CD59; LY6D; LY6E; LY6H; LYNX1;LYPD2; LYPD3; LYPD4; LYPD5; LYPD6; PLAUR; PSCA;
SLURP2; SLURP1; SPACA4; TEX101;