Lactate dehydrogenase A

Lactate dehydrogenase A is an enzyme which in humans is encoded by the LDHA gene. It is a monomer of lactate dehydrogenase, which exists as a tetramer. The other main subunit is lactate [dehydrogenase B].

Function

Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD⁺. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.

LDHA Inhibitors

The following compounds have been demonstrated to inhibit the LDHA enzyme: