John Spence
John Spence may refer to:
- John Spence (frogman), American World War II veteran, first American combat frogman
- John Spence (musician), founding member of the band No Doubt
- John Spence (politician), British Conservative MP 1970–1986
- John Spence (sailor), British sailor, won silver medal at 1908 Summer Olympics
- John Spence (scientist), Trinidadian botanist and politician
- John C. Spence (artist), a stained-glass artist and painter in Montreal, Canada
- John C. H. Spence, Richard Snell Professor of Physics at Arizona State University
- John S. Spence, American Senator from Maryland
- John Selby Spence (bishop)
- John David Spence, Canadian medical doctor, medical researcher and professor
- John Brodie Spence, banker and politician in South Australia
- John Spence (footballer), footballer for Sunderland
- John Spence (zoo director), South Africa
- John P. Spence (politician) Ontario politician
- John Spence (entrepreneur), a British-born founder and chairman of the Karma Group