John Spence
John Spence may refer to:
- John Spence , American World War II veteran, first American combat frogman
- John Spence , founding member of the band No Doubt
- John Spence , British Conservative MP 1970–1986
- John Spence , British sailor, won silver medal at 1908 Summer Olympics
- John Spence , Trinidadian botanist and politician
- John C. Spence , a stained-glass artist and painter in Montreal, Canada
- John C. H. Spence, Richard Snell Professor of Physics at Arizona State University
- John S. Spence, American Senator from Maryland
- John Selby Spence
- John David Spence, Canadian medical doctor, medical researcher and professor
- John Brodie Spence, banker and politician in South Australia
- John Spence, footballer for Sunderland
- John Spence, South Africa
- John P. Spence Ontario politician
- John Spence, a British-born founder and chairman of the Karma Group