James Shepherd
James Shepherd may refer to:
- James Shepherd (rugby league), Australian rugby league footballer
- James Shepherd (Australian cricketer), Australian cricketer
- James Shepherd (New Zealand cricketer), New Zealand cricketer
- James E. Shepherd, lawyer and jurist who served on the North Carolina Supreme Court
- James Shepherd (biochemist), pioneer in the investigation of the causes, prevention and treatment of coronary heart disease
- James Shepherd (missionary), Australian-born Wesleyan Christian missionary and settler in New Zealand
- James Shepherd (doctor), physician and missionary
- James Shepherd (musician), English cornet soloist and founder of James Shepherd Versatile Brass