James O'Brien
James O'Brien may refer to:
Politicians
- James O'Brien (died 1771), Irish nobleman and politician
- James O'Brien (1806–1882), Irish judge and British MP for Limerick City
- James O'Brien (Canadian politician), Canadian senator
- James O'Brien (New Brunswick politician), Canadian blacksmith and political figure in New Brunswick
- James O'Brien (New Zealand politician), New Zealand politician
- James O'Brien (U.S. Congressman), United States Representative from New York
- James Bronterre O'Brien, Irish-born Chartist leader, reformer and journalist
- J. F. X. O'Brien, Irish rebel and British MP
- James H. O'Brien, United States Representative from New York
- Jay O'Brien (Virginia politician), American politician in Virginia
- James C. O'Brien, Assistant Secretary of State for European and Eurasian Affairs during the Biden administration
- James William O'Brien, American farmer and politician
Others
- James O'Brien, 3rd Marquess of Thomond, British naval officer
- James O'Brien (broadcaster), British journalist and presenter, primarily on LBC radio
- James O'Brien (sprinter), Canadian sprinter
- James O'Brien (hurler), Irish hurler
- James O'Brien (internet radio), Canadian internet radio journalist, founder and producer of RantMedia
- James O'Brien (oceanographer), American oceanographer
- James O'Brien (piper), Irish musician
- James F. O'Brien, American computer graphics researcher
- James O'Brien (filmmaker), American film director, screenwriter and producer
- James Joseph O'Brien, British clergyman
- James O'Brien (horticulturist), winner of the Victoria Medal of Honour
- James O'Brien (sprinter, born 1896), American sprinter and winner of the 300 yards at the 1921 USA Indoor Track and Field Championships
- James O'Brien, Australian musician, bassist for The Boat People
- James J. O'Brien was one of many known aliases used by con artist George C. Parker