James Little
James Little may refer to:
- James Little , Wisconsin State Assemblyman
- James Little , unionist politician in Northern Ireland
- James Little , Irish physician
- James-Little [Ecological Reserve]
- Jimmy Little, Australian Aboriginal musician, singer and songwriter
- Jim Little , CEO of Ottawa Senators, 2020
- Jimmy Little , carpenter, stagehand and TV personality
- James Little , New Zealand shepherd and sheep breeder
- James Little , American labor union leader
- James Lewis Little, schooner captain and politician in Newfoundland
- James Little , American painter