James Humphreys

• James Humphreys (printer), American-born publisher & politician
• James Humphreys (lawyer), British lawyer, writer and law reformer
• James Humphreys (pornographer), British operator of adult book shops and strip clubs
• James E. Humphreys, American mathematician
• James Humphreys (author), British political strategist and fiction writer
• Jimmy Humphreys, Irish hurler