Isomescaline

Isomescaline, also known as 2,3,4-trimethoxyphenethylamine or as TMPEA-3 or 2C-TMA-3, is a chemical compound related to mescaline. It is a positional isomer of mescaline, as well as an analogue of TIM-2, TIM-3, and TIM-4. In his book PiHKAL, Alexander Shulgin lists its dose as greater than 400mg orally and its duration as unknown. Despite its structural similarity to mescaline, isomescaline produced no effects in humans. Very little data exists about the pharmacological properties, metabolism, and toxicity of isomescaline. Isomescaline was first described in the scientific literature by Clark and colleagues by 1965. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991. Isomescaline is not a controlled substance in Canada as of 2025.