Indriline


Indriline is a central nervous system stimulant with antidepressant activity and application in the treatment of gastric ulcers.
A patent using this chemical is assigned to: Pharmacology.

Synthesis

The chemical synthesis of indriline has been described:
Treatment of 3-phenylindene with n-butyl lithium and dimethylamino-2-choroethane gave indriline as well as some inactive isomer. Based on neighboring group participation, the reaction intermediate is presumably an aziridinium ion
According to Molbase the number of routes for preparing the starting 3-phenylindene is rich. For example from dihydrochalcone.
A more classical synthesis is also described in a Pyrophendane patent.