| Title | Released | Developer | Publisher |
| E-racer | 2001 | Rage Software | Rage Software |
| E.Y.E.: Divine Cybermancy | 2011 | Streum On Studio | Streum On Studio |
| EA Sports GameShow | 2007 | EA Tiburon | EA Sports |
| Earache: Extreme Metal Racing | 2006 | Data Design Interactive | Data Design Interactive |
| Earth & Beyond | 2002 | Westwood Studios | Electronic Arts |
| Earth 2140 | 1997 | Reality Pump Studios | TopWare Interactive, Interplay Productions |
| Earth 2150 | 2000 | Reality Pump Studios | TopWare Interactive, Mattel Interactive |
| Earth 2150: Lost Souls | 2001 | TopWare Interactive | Blackstar Interactive, Strategy First |
| Earth 2150: The Moon Project | 2000 | TopWare Interactive | Strategic Simulations, Inc. |
| Earth 2160 | 2005 | Reality Pump | Deep Silver |
| Earthlock | 2016 | Snowcastle Games | Snowcastle Games |
| Earthrise | 2009 | Masthead Studios | Iceberg Interactive |
| Earthsiege 2 | 1996 | Dynamix | Sierra On-Line |
| Earthworm Jim | 1995 | Shiny Entertainment | Activision |
| Earthworm Jim 3D | 2000 | VIS Entertainment | Interplay Entertainment |
| East India Company | 2009 | Nitro Games | Paradox Interactive |
| Eastshade | 2019 | Eastshade Studios | Eastshade Studios |
| Ecco the Dolphin | 2010 | Novotrade International | Sega |
| Echelon | 2001 | MADia Entertainment | BUKA |
| Echo | 2017 | Ultra Ultra | Ultra Ultra |
| Echo: Secrets of the Lost Cavern | 2005 | Kheops Studio | The Adventure Company |
| Ecstatica II | 1997 | Andrew Spencer Studios | Psygnosis |
| Ed, Edd n Eddy: The Mis-Edventures | 2005 | Artificial Mind and Movement | Midway Games |
| eden* | 2009 | Minori | Minori, MangaGamer |
| Edge | 2011 | Two Tribes | Mobigame |
| Edge of Twilight | 2009 | Fuzzyeyes | SouthPeak Games |
| Edna & Harvey: Harvey's New Eyes | 2012 | Daedalic Entertainment | Daedalic Entertainment |
| Edna & Harvey: The Breakout | 2008 | Daedalic Entertainment | Daedalic Entertainment |
| Eets | 2006 | Klei Entertainment | Klei Entertainment |
| Ef: The First Tale | 2006 | Minori | Minori, MangaGamer |
| Ef: The Latter Tale | 2008 | Minori | Minori, MangaGamer |
| Eggerland Episode 0: Quest of Rara | 1996 | Avit | HAL Corporation |
| Egoboo | 1999 | Egoboo Development Team | Ben Bishop |
| Egypt Kids | 2001 | EMG | Cryo Interactive |
| Eidolon | 2014 | Ice Water Games | Ice Water Games |
| El Paso, Elsewhere | 2023 | Strange Scaffold | Strange Scaffold |
| Elasto Mania | 2000 | Balazs Rozsa | Independent |
| Elden Ring | 2022 | FromSoftware | Bandai Namco Entertainment |
| The Elder Scrolls III: Bloodmoon | 2003 | Bethesda Softworks | Bethesda Softworks |
| The Elder Scrolls III: Morrowind | 2002 | Bethesda Game Studios | Bethesda Softworks, Ubisoft |
| The Elder Scrolls III: Tribunal | 2002 | Bethesda Softworks | Bethesda Softworks |
| The Elder Scrolls IV: Oblivion | 2006 | Bethesda Softworks | 2K Games |
| The Elder Scrolls IV: Shivering Isles | 2007 | Bethesda Game Studios | Bethesda Softworks, 2K Games |
| The Elder Scrolls V: Skyrim | 2011 | Bethesda Game Studios | Bethesda Softworks |
| Elemental: War of Magic | 2010 | Stardock | Stardock |
| Elements of Destruction | 2007 | Frozen Codebase | THQ |
| ELEX | 2017 | Piranha Bytes | THQ Nordic |
| ELEX 2 | 2022 | Piranha Bytes | THQ Nordic |
| Elf Bowling | 1999 | NStorm, Inc. | NStorm, Inc. |
| Elite Warriors: Vietnam | 2005 | nFusion | Infogrames |
| Elven Legacy | 2009 | 1C Company | Paradox Interactive |
| Ember | 2016 | N-Fusion Interactive | 505 Games |
| Embodiment of Scarlet Devil | 2002 | Team Shanghai Alice | Team Shanghai Alice |
| Emerald City Confidential | 2009 | Wadjet Eye Games | PlayFirst |
| Emergency | 1998 | Sixteen Tons Entertainment | Arush Entertainment |
| Emergency Fire Response | 2003 | Monte Cristo Multimedia | DreamCatcher Interactive |
| Emily Wants to Play | 2015 | Shawn Hitchcock | Hitchcock Games |
| Emperor: Battle for Dune | 2001 | Intelligent Games, Westwood Studios | EA Games |
| Emperor: Rise of the Middle Kingdom | 2002 | BreakAway Games, Impressions Games | Sierra Entertainment |
| Empire Earth | 2001 | Stainless Steel Studios | Sierra Entertainment |
| Empire Earth: The Art of Conquest | 2002 | Mad Doc Software | Sierra Entertainment |
| Empire Earth II | 2005 | Mad Doc Software | Vivendi Universal |
| Empire Earth II: The Art of Supremacy | 2006 | Mad Doc Software | Vivendi Universal |
| Empire Earth III | 2007 | Mad Doc Software | Sierra Entertainment |
| Empire in Arms: The Napoleonic Wars of 1805–1815 | 2004 | Outflank Strategy Wargames | Matrix Games |
| Empire of the Ants | 2000 | Microids | Microids |
| Empire of the Ants | 2024 | Tower Five | Microids |
| Empire: Total War | 2009 | The Creative Assembly | Sega |
| Empires: Dawn of the Modern World | 2003 | Stainless Steel Studios | Activision |
| Empyrion - Galactic Survival | 2020 | Eleon Game Studios | Eleon Game Studios |
| Enclave | 2002 | Starbreeze Studios | Vivendi Universal Games |
| Endless Ages | 2003 | Avaria Corporation | SummitSoft Entertainment |
| Endless Legend | 2014 | Amplitude Studios | Iceberg Interactive, Sega |
| Endless Space | 2012 | Amplitude Studios | Iceberg Interactive, Sega |
| Endless Space 2 | 2017 | Amplitude Studios | Sega |
| Endorfun | 1995 | Onesong Partners | Time Warner Interactive |
| Endzone: A World Apart | 2021 | Gentlymad Studios | Assemble Entertainment |
| Enemy Engaged 2 | 2007 | G2 CES | G2 Games |
| Enemy Engaged: RAH-66 Comanche vs. KA-52 Hokum | 2000 | Razorworks | Empire Interactive |
| Enemy Front | 2014 | CI Games | CI Games |
| Enemy Nations | 1997 | Windward Studios | Head Games Publishing |
| Enemy Territory: Quake Wars | 2007 | Splash Damage, id Software | Activision |
| Enemy Zero | 1996 | WARP | Sega |
| Enigma: Rising Tide | 2003 | Tesseraction Games | Dreamcatcher Interactive |
| Enigmo | 2003 | Pangea Software | Pangea Software |
| Enslaved: Odyssey to the West | 2013 | Ninja Theory | Namco Bandai Games |
| Enter the Matrix | 2003 | Shiny Entertainment | Atari, Warner Bros. Interactive Entertainment |
| Entomorph: Plague of the Darkfall | 1995 | Cyberlore Studios | Mindscape |
| Entropia Universe | 2003 | MindArk, FPC | MindArk, FPC |
| The Entropy Centre | 2022 | Stubby Games | Playstack |
| Eragon | 2006 | Stormfront Studios | Vivendi Universal Games |
| Escape Dead Island | 2014 | Fatshark | Deep Silver |
| Escape from Monkey Island | 2000 | LucasArts | LucasArts |
| Escape From Paradise City | 2007 | Sirius Games | CDV Software |
| Escape Velocity Nova | 2002 | Ambrosia Software, ATMOS | Ambrosia Software |
| Eschalon: Book I | 2007 | Basilisk Games | Basilisk Games |
| Eschalon: Book II | 2009 | Basilisk Games | Basilisk Games |
| The Eternal Cylinder | 2021 | ACE Team | Good Shepherd Entertainment |
| Eternal Fantasy | 2007 | Circus | Circus |
| Eternity's Child | 2008 | Luc Bernard, Silver Sphere Studios | Silver Sphere Studios |
| Ether One | 2014 | White Paper Games | White Paper Games |
| Eufloria | 2009 | Omni Systems Limited | Headup Games |
| Euro Truck Simulator | 2008 | SCS Software | SCS Software, Excalibur Publishing, Meridian4 |
| Eurofighter | 2001 | Digital Image Design, Rage Software | Rage Software |
| Europa 1400: The Guild | 2002 | 4HEAD Studios | JoWood Productions |
| Europa Universalis | 2000 | Paradox Interactive | Strategy First, Typhoon Games |
| Europa Universalis II | 2001 | Paradox Interactive | Strategy First |
| Europa Universalis III | 2007 | Paradox Interactive | Paradox Interactive |
| Europa Universalis IV | 2013 | Paradox Development Studio | Paradox Interactive |
| Europa Universalis: Crown of the North | 2000 | Paradox Entertainment | Levande Böcker, PAN Vision, Strategy First |
| Europa Universalis: Rome | 2008 | Paradox Interactive | Paradox Interactive |
| European Air War | 1998 | MicroProse | MicroProse |
| EVE Burst Error | 1997 | C's Ware | C's Ware |
| Eve Online | 2003 | CCP Games | SSI, CCP Games |
| Event 0 | 2016 | Ocelot Society | Ocelot Society |
| Ever 17: The Out of Infinity | 2002 | KID | KID, Hirameki International |
| EverQuest | 1999 | Sony Online Entertainment | Sony Online Entertainment |
| EverQuest II | 2004 | Sony Online Entertainment | Sony Online Entertainment, Gamania, Akella, Square Enix, Ubisoft |
| Eversion | 2010 | Zaratustra Productions | Zaratustra Productions |
| Everspace | 2017 | Rockfish Games | Rockfish Games |
| Everspace 2 | 2023 | Rockfish Games | Rockfish Games |
| Everybody's Gone to the Rapture | 2016 | The Chinese Room | Sony Computer Entertainment |
| Everyday Shooter | 2007 | Queasy Games | Valve |
| Everything | 2017 | David OReilly | Double Fine Productions |
| Evidence: The Last Report | 1996 | Microïds | Microïds |
| Evidence: The Last Ritual | 2006 | Lexis Numerique | Ubisoft, The Adventure Company |
| Evil Dead: Hail to the King | 2000 | Heavy Iron Studios | THQ |
| Evil Dead: Regeneration | 2005 | Cranky Pants Games | THQ |
| Evil Dead: The Game | 2022 | Saber Interactive | Boss Team Games |
| Evil Genius | 2004 | Elixir Studios | Sierra Entertainment |
| Evil Islands: Curse of the Lost Soul | 2000 | Nival Interactive | Nival Interactive |
| Evil Twin: Cyprien's Chronicles | 2001 | In Utero | Ubisoft |
| Evil West | 2022 | Flying Wild Hog | Focus Entertainment |
| The Evil Within | 2014 | Tango Gameworks | Bethesda Softworks |
| The Evil Within 2 | 2017 | Tango Gameworks | Bethesda Softworks |
| Evochron Alliance | 2007 | StarWraith 3D Games | StarWraith 3D Games |
| Evochron Legends | 2009 | StarWraith 3D Games | StarWraith 3D Games |
| Evochron Renegades | 2007 | StarWraith 3D Games | StarWraith 3D Games |
| Evoland | 2013 | Shiro Games | Shiro Games |
| Evoland 2 | 2015 | Shiro Games | Shiro Games |
| Evolution: The Game of Intelligent Life | 1997 | Crossover Technologies | Interplay Entertainment, Discovery Channel Multimedia |
| Evolva | 2000 | Computer Artworks Ltd. | Interplay Entertainment |
| Evolve | 2015 | Turtle Rock Studios | 2K |
| Ex Zeus | 2005 | Hyper-Devbox Japan | Hyper-Devbox Japan, Conspiracy Entertainment, 505 Games, Metro3D |
| Excalibur 2555 AD | 1997 | Tempest Software | Sir-tech |
| The Exit 8 | 2023 | Kotake Create | Kotake Create |
| Exo One | 2021 | Exbleative | Future Friends Games |
| Expeditions: A MudRunner Game | 2024 | Saber Interactive | Focus Entertainment |
| Expeditions: Conquistador | 2013 | Logic Artists | BitComposer |
| Expeditions: Rome | 2022 | Logic Artists | THQ Nordic |
| Expeditions: Viking | 2017 | Logic Artists | Logic Artists |
| EXperience112 | 2007 | Lexis Numerique | Micro Application |
| Explodemon | 2009 | Curve Studios | Curve Studios |
| Exteel | 2007 | NCsoft | NCsoft |
| Extinction | 2018 | Iron Galaxy | Modus Games |
| Extreme Paintbrawl | 1998 | Creative Carnage | Head Games Publishing |
| Extreme Rock Climbing | 1999 | Creative Carnage | Head Games Publishing |
| Extreme-G 2 | 1998 | Probe Entertainment | Acclaim Entertainment |