21st Independent Spirit Awards
The 21st Independent Spirit Awards, honoring the best in independent filmmaking for 2005, were announced on March 4, 2006. It was hosted by Sarah Silverman.
Winners and nominees
Films with multiple nominations and awards
| Awards | Film |
| 2 | Brokeback Mountain |
| 2 | Capote |
| 2 | Crash |
| 2 | Transamerica |
Special awards
[Independent Spirit [John Cassavetes Award|John Cassavetes Award]]
Conventioneers- Brick
- Jellysmoke
- The Puffy Chair
- ''Room''
Truer Than Fiction Award
Occupation: DreamlandProducers Award
Caroline Baron - Capote and Monsoon Wedding- Ram Bergman - Brick and Conversations with Other Women
- Mike S. Ryan - Junebug and ''Palindromes''
Someone to Watch Award
Ian Gamazon and Neill Dela Llana - Cavite- Robinson Devor - Police Beat
- Jay Duplass - ''The Puffy Chair''