Lewis made her on-screen debut in the musical drama series The Get Down. She also appeared in Alternatino with Arturo Castro, and Wu-Tang: An American Saga early on in her career Her first recurring role came playing Karen in the music drama series Star. Her first big role came playing Calliope Burns in the supernatural teen series First Kill. Her character is a lesbian who gets into a relationship with Sarah CatherineHook. She played a lead role in the crime drama series Hightown.