ISC
- (ISC)²
- ICS (disambiguation)
- ISC (sportswear)
- ISC license
- ISCC (disambiguation)
- ISSC (disambiguation)
- Imperial Space Command
- Independent Schools Council
- Indian School Certificate
- Indian Society of Cinematographers
- Indigenous Services Canada
- Indonesia Soccer Championship
- Indonesia Soccer Championship A
- Indonesia Soccer Championship B
- Infiltration Surveillance Center
- Information Services Corporation
- Initiative for Software Choice
- Institut supérieur du commerce de Paris
- Intelligence and Security Committee
- Interactive Systems Corporation
- International School of Carthage
- International School of Curitiba
- International Science Council
- International Sculpture Center
- International Seismological Centre
- International Shooto Commission
- International Signal and Control
- International Silver Company
- International Socialist Commission
- International Softball Congress
- International Speedway Corporation
- International Sportsworld Communicators
- International Supercomputing Conference
- International Union of Students
- Internet Scrabble Club
- Internet Storm Center
- Internet Systems Consortium
- Intersystem crossing
- Intervision Song Contest
- Inverse Symbolic Calculator
- Iron–sulfur cluster biosynthesis protein family
- Islamic World Science Citation Database
- Kandersteg International Scout Centre
- St Mary's Airport, Isles of Scilly
- St. Gallen Symposium
- Tiger Zinda Hai
- Uniform Certified Public Accountant Examination
- United States Postal Service