ISSC (disambiguation)
- IBM Global Services
- ISC (disambiguation)
- ISCC (disambiguation)
- Instituto Salesiano
- International Social Science Council
- International Solid-State Circuits Conference
- Interstate Shellfish Sanitation Conference
- Isles of Scilly Steamship Company
- Large Synoptic Survey Telescope
- Microchip Technology
- Rockingham Motor Speedway
- University of Pune