Hydrazine (antidepressant)
The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.
Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.
List of hydrazine antidepressants
Marketed
- Benmoxin ‡
- Iproclozide ‡
- Iproniazid ‡Isocarboxazid
- Mebanazine ‡
- Nialamide ‡
- Octamoxin ‡Phenelzine
- Pheniprazine ‡
- Phenoxypropazine ‡
- Pivhydrazine ‡
- Safrazine ‡
Never marketed
[Parkinson's]
Tranquillosedative
- Centazolone