Pheniprazine
Pheniprazine, formerly sold under the brand names Catron and Cavodil, is an irreversible and non-selective monoamine oxidase inhibitor of the hydrazine group that was used as an antidepressant to treat depression in the 1960s. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.
Pharmacology
Pheniprazine is a monoamine oxidase inhibitor.Amphetamine has been detected as an active metabolite of pheniprazine in animals. Pheniprazine produces amphetamine- and psychostimulant-like effects at high doses in animals. The same is true of certain other MAOIs, including iproniazid, phenelzine, tranylcypromine, and pargyline, but not nialamide.
Chemistry
Pheniprazine, also known as α-methylphenethylhydrazine, is a phenethylamine, amphetamine, and hydrazine derivative.It is a close analogue of phenelzine and amphetamine and can also be referred to by synonyms including amphetamine hydrazide, α-methylphenelzine, and N-aminoamphetamine.
Metfendrazine is the corresponding methamphetamine analogue.