Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing is a scholarly work by Tony Kouzarides and Blerta Xhemalce, published in 2012 in ''Cell''. The main subjects of the publication include methylation, genetics, epigenetics, Dicer 1, ribonuclease III, negative regulation of pre-miRNA processing, long non-coding RNA, Drosha ribonuclease III, methyltransferase, microRNA, molecular biology, RNA interference, cell biology, BCDIN3 domain containing RNA methyltransferase, Ribonuclease III, biogenesis, ribonucleic acid, ribonuclease P, and biology. Specifically, authors show that BCDIN3D phospho-dimethylates pre-miR-145 both in vitro and in vivo and that phospho-dimethylated pre-miR-145 displays reduced processing by Dicer in vitro.