Hotspots of Biased Nucleotide Substitutions in Human Genes
Hotspots of Biased Nucleotide Substitutions in Human Genes is a scholarly work by Matthew T Webster and Katherine Pollard, published in 2009 in ''PLOS Biology''. The main subjects of the publication include GC-content, Synonymous substitution, evolutionary biology, lineage, bias, coding region, ribosome, biology, gene, genome, Nonsynonymous substitution, purifying selection, genetics, gene conversion, Genome evolution, Concerted evolution, fixation, human genome, RNA sequencing, exon, polyploidy, and molecular evolution. The authors next analyzed genes with significantly elevated ratios of nonsynonymous to synonymous rates of base substitution (dN/dS) along the human lineage, and those with an excess of amino acid replacement substitutions relative to human polymorphism.