List of highways numbered 380
Route 380 or Highway 380 may refer to:
Canada
- New Brunswick Route 380
- Newfoundland and Labrador Route 380
Japan
- Japan National Route 380
United States
- Interstate 380
- U.S. Route 380
- Arizona State Route 380
- Arkansas Highway 380
- Georgia State Route 380
- Louisiana Highway 380
- Maryland Route 380
- New York State Route 380
- Ohio State Route 380
- Oregon Route 380
- Pennsylvania Route 380
- Puerto Rico Highway 380
- Tennessee State Route 380