List of highways numbered 378
The following highways are numbered 378:
Canada
- Saskatchewan Highway 378
Japan
- Japan National Route 378
United States
- Interstate 378
- U.S. Route 378
- Georgia State Route 378
- Louisiana Highway 378
- Maryland Route 378
- Nevada State Route 378
- New Mexico State Road 378
- New York State Route 378
- Ohio State Route 378
- Pennsylvania Route 378
- Puerto Rico Highway 378
- Virginia State Route 378