HOCOMOCO


HOCOMOCO
is an open-access database providing curated and benchmarked binding motifs of human and mouse transcription factors. It captures the following data types: Homo sapiens and Mus musculus transcription factors, their DNA binding site motifs, and motif subtypes.

Introduction

Transcription factors are proteins that bind DNA and thus regulate the transcription process. The binding is sequence-specific. A sequence motif is a model that describes the common pattern of the DNA binding sites that a particular TF prefers to bind. One of the possible representations of the model is the Position-Weight Matrix (PWM).

Organisms

Homo sapiens

Recognition

According to the Web of Science, the 2018 publication of HOCOMOCO has been cited 396 times. The publications have been cited 144 and 151 times.