HFS
- Croatian Film Association
- French Frigate Shoals Airport
- H. F. S. Morgan
- HF (disambiguation)
- HFSS (disambiguation)
- HTTP File Server
- Haddonfield Friends School
- Hagfors Airport
- Hardware functionality scan
- Harford Friends School
- Hatfield and Stainforth railway station
- Hellenic Fire Service
- Hemifacial spasm
- Hereditarily finite set
- Hexafluorosilicic acid
- Hierarchical File System (Apple)
- Hierarchical File System (IBM MVS)
- Hierarchical file system
- High Performance File System
- High fructose syrup
- Hiranandani Foundation Schools
- Hospitality Franchise Systems
- Hydrogen forward scattering
- Hyperfine structure
- Unix File System
- WHFS (historic)