Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling
Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling is a scholarly work by Wei Huang, Lingfei Luo, and Sizhou Huang, published in 2018 in ''BioMed Research International''. The main subjects of the publication include genetics, paraxial mesoderm, anatomy, mesoderm, transcription factor, biology, Notch signaling pathway, fibroblast growth factor family, FGF8, somite, somitogenesis, cell biology, Wnt signaling pathway, and development of the heart. The authors demonstrate that the loss of function of geminin gave rise to narrower somites as a result of derepressed Fgf8 gradient in the PSM and tail bud.