Francis Clerke

• Francis Clerke (lawyer), English lawyer
• Francis Clerke (politician, died 1686), English politician, MP for Rochester
• Francis Clerke (politician, died 1715), English politician, MP for Oxfordshire
• Francis Clerke (politician, died 1691), English politician, MP for Rochester
• Sir Francis Clerke, 6th Baronet, of the Clerke baronets, Gentleman Usher
• Sir Francis Clerke, 7th Baronet, aide-de-camp to General John Burgoyne, killed at Saratoga