Ethacizine


Ethacizine is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome.
It is manufactured under the brand name Ethacizin by Latvian pharmaceutical company Olainfarm.

Synthesis

For the treatment of heart infarction:
The amide formation between Phenothiazine-2-ethylcarbamate and 3-Chloropropionyl chloride gives ethyl N-carbamate . Displacement of the remaining ω-halogen by diethylamine then completes the synthesis of ethacizine.