Estimate of the Mutation Rate per Nucleotide in Humans
Estimate of the Mutation Rate per Nucleotide in Humans is a scholarly work, published in 2000 in ''Genetics''. The main subjects of the publication include genetics, mutation, mutation rate, ribosome, DNA repair, nucleotide, evolutionary dynamics, and biology. The authors investigated the rate and pattern of mutations at the nucleotide level by comparing pseudogenes in humans and chimpanzees to (i) provide an estimate of the average mutation rate per nucleotide, (ii) assess heterogeneity of mutation rate at different sites and for different types of mutations, (iii) test the hypothesis that the X chromosome has a lower mutation rate than autosomes, and (iv) estimate the deleterious mutation rate.