Epistasis Increases the Rate of Conditionally Neutral Substitution in an Adapting Population
Epistasis Increases the Rate of Conditionally Neutral Substitution in an Adapting Population is a scholarly work by Joshua B. Plotkin, published in 2011 in ''Genetics''. The main subjects of the publication include epistasis, evolutionary dynamics, genetic variation, mutation rate, genetic model, evolutionary biology, genetic drift, biology, molecular clock, neutral theory of molecular evolution, natural selection, genetics, mutation, neutral mutation, physiological adaptation, effective population size, population genetics, RNA sequencing, molecular evolution, population, and selection (genetic algorithm). The authors quantify these effects using a simple population-genetic model that elucidates how the substitution rate at conditionally neutral sites depends on the population size, mutation rate, strength of selection, and prevalence of epistasis.