List of Dutch Top 40 number-one singles of 2006
This is a list of the Dutch Top 40 number-one singles of 2006. The Dutch Top 40 is a chart that ranks the best-performing singles of the Netherlands. It is published by radio station Radio 538.
Chart history
| Issue date | Song | Artist | Reference |
| 7 January | "Talk" | Coldplay | |
| 14 January | "Talk" | Coldplay | |
| 21 January | "Talk" | Coldplay | |
| 28 January | "Because of You" | Kelly Clarkson | |
| 4 February | "Because of You" | Kelly Clarkson | |
| 11 February | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 18 February | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 25 February | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 4 March | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 11 March | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 18 March | "Because We Believe" | Andrea Bocelli featuring Marco Borsato | |
| 25 March | "Right Here Right Now" | Raffaëla Paton | |
| 1 April | "Right Here Right Now" | Raffaëla Paton | |
| 8 April | "Right Here Right Now" | Raffaëla Paton | |
| 15 April | "Right Here Right Now" | Raffaëla Paton | |
| 22 April | "Right Here Right Now" | Raffaëla Paton | |
| 29 April | "Hips Don't Lie" | Shakira featuring Wyclef Jean | |
| 6 May | "Hips Don't Lie" | Shakira featuring Wyclef Jean | |
| 13 May | "Rood" | Marco Borsato | |
| 20 May | "Rood" | Marco Borsato | |
| 27 May | "Rood" | Marco Borsato | |
| 3 June | "Rood" | Marco Borsato | |
| 10 June | "Rood" | Marco Borsato | |
| 17 June | "Rood" | Marco Borsato | |
| 24 June | "Rood" | Marco Borsato | |
| 1 July | "Rood" | Marco Borsato | |
| 8 July | "Rood" | Marco Borsato | |
| 15 July | "Rood" | Marco Borsato | |
| 22 July | "Rood" | Marco Borsato | |
| 29 July | "Mas Que Nada" | Sérgio Mendes featuring Black Eyed Peas | |
| 5 August | "Mas Que Nada" | Sérgio Mendes featuring Black Eyed Peas | |
| 12 August | "Toppertje!" | Guillermo & Tropical Danny | |
| 19 August | "Toppertje!" | Guillermo & Tropical Danny | |
| 26 August | "Boten Anna" | Basshunter | |
| 2 September | "Boten Anna" | Basshunter | |
| 9 September | "Als De Morgen Is Gekomen" | Jan Smit | |
| 16 September | "Als De Morgen Is Gekomen" | Jan Smit | |
| 23 September | "Als De Morgen Is Gekomen" | Jan Smit | |
| 30 September | "Als De Morgen Is Gekomen" | Jan Smit | |
| 7 October | "Als De Morgen Is Gekomen" | Jan Smit | |
| 14 October | "Everytime I Think of You" | Marco Borsato & Lucie Silvas | |
| 21 October | "Everytime I Think of You" | Marco Borsato & Lucie Silvas | |
| 28 October | "Everytime I Think of You" | Marco Borsato & Lucie Silvas | |
| 4 November | "Everytime I Think of You" | Marco Borsato & Lucie Silvas | |
| 11 November | "Everytime I Think of You" | Marco Borsato & Lucie Silvas | |
| 18 November | "The Saints Are Coming" | U2 & Green Day | |
| 25 November | "The Saints Are Coming" | U2 & Green Day | |
| 2 December | "Paniek in De Confettifabriek" | Coole Piet | |
| 9 December | "Cupido" | Jan Smit | |
| 16 December | "Cupido" | Jan Smit | |
| 23 December | "Cupido" | Jan Smit | |
| 30 December | "Cupido" | Jan Smit |