Dimenoxadol
Dimenoxadol is an opioid analgesic which is a benzilic acid derivative, closely related to benactyzine. Further, the structure is similar to methadone and related compounds like dextropropoxyphene.
It was invented in Germany in the 1950s, and produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.
In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9617 and a 2013 annual aggregate manufacturing quota of zero.
Synthesis
The chemical synthesis has been reported: Ref: Patent: Cmp#3:- The reaction between 2-chloro-2,2-diphenylacetyl chloride and Deanol gives . The intermediate haloalkane is then alkoxylated by refluxing in ethanol, completing the synthesis of Dimenoxadol.
- The 2-chloro-2,2-diphenylacetyl chloride is made by reacting benzilic acid with phosphorus pentachloride.