Despair (disambiguation)
- Depression (mood)
- Despair (DC Comics)
- Despair (album)
- Despair (band)
- Despair (film)
- Despair (novel)
- Despair (sculpture)
- Despair, Inc.
- Desperate (disambiguation)
- Diseases of despair
- Mosquito (Yeah Yeah Yeahs album)
- Mount Despair (Washington)
- Neka mi ne svane
- Robert Crumb
- Strange Academy
- The Pilgrim's Progress