Designing one-sided group sequential clinical trials to detect a mixture alternative
Designing one-sided group sequential clinical trials to detect a mixture alternative is a scholarly work, published in 2018 in ''Sequential Analysis''. The main subjects of the publication include variance, sample, pharmaceutical industry, type I and type II errors, design of experiments, stopping time, clinical trial, statistics, estimator, test, optimal stopping, early stopping, mathematics, sample size determination, and sequential analysis. The authors demonstrate the need for larger arm sizes when trying to detect a mixture alternative compared to trying to detect a pure shift alternative.