Deltex e3 ubiquitin ligase 3

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene. It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c. DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.

Function

DTX3 functions as an E3 ubiquitin ligase. Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.