2,5-Dimethoxy-4-hexylamphetamine
2,5-Dimethoxy-4-hexylamphetamine is a non-hallucinogenic serotonin receptor modulator of the phenethylamine, amphetamine, and DOx families.
Pharmacology
Pharmacodynamics
DOHx has shown the highest affinity for the serotonin 5-HT2A and 5-HT2C receptors of any other assessed DOx drug in multiple studies. In one study, its affinities for the human serotonin 5-HT2 receptors were 0.1nM for the 5-HT2A receptor, 30nM for the 5-HT2B receptor, and 0.7nM for 5-HT2C receptor. In the case of the serotonin 5-HT2A receptor, this was 6- to 14-fold higher than DOB, DOI, and DOC and was 9-fold higher than DOPR. In another study, DOHx showed 25-fold higher affinity for the serotonin 5-HT2A receptor than DOM or DOET, 23- to 28-fold higher affinity than DOPR and DOBU, and 2.8-fold higher affinity than DOAM. Conversely, it showed only slightly higher or roughly the same affinity for the receptor relative to DOCT.In contrast to many other DOx drugs, DOHx, as well as related drugs like DOCT, have been found to act as serotonin 5-HT2 receptor antagonists rather than as an agonists, and hence would not be expected to be serotonergic psychedelics. In accordance, DOHx, DOCT, and other related drugs do not produce DOM-like effects in rodent drug discrimination tests. DOHx has also been assessed and found to act as a silent antagonist of the serotonin 5-HT2B receptor.