DOH-5-hemiFLY
DOH-5-hemiFLY, or DMA-hemiFly-5, also known as semi-fly, is a serotonin receptor modulator and putative psychedelic drug of the phenethylamine, amphetamine, DOx, and benzofuran families related to 2,5-dimethoxyamphetamine. It is a cyclized derivative of 2,5-DMA related to the FLY psychedelics. The drug shows affinity for the serotonin 5-HT2A receptor and fully substitutes for LSD in rodent drug discrimination tests, albeit with relatively low potency. The chemical synthesis of DOH-5-hemiFLY has been described. DOH-5-hemiFLY was first described in the scientific literature by David E. Nichols and colleagues in 1991.