Awiti began his career working for Kenya's Ministry of Public Works as an Electrical Inspector, he left after a few years and began working at Mombasa Polytechnic as a Senior lecturer. In 1993, he was appointed country director at Marie Stopes Kenya where he served there till 2010. In 2013 he was elected Governor of Homa Bay County.
Controversy
On July 14, 2015, Cyprian Awiti was summoned by the Senate Committee on County Public Accounts to explain how he spent Sh11.8 million on renovation of the Governor's office through a tender given through restrictive process few days after his assumption of office.