Corbadrine
Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.
The drug acts as a non-selective agonist of the α1-, α2-, and β-adrenergic receptors. It is said to have preferential activity at the α2-adrenergic receptor.
Corbadrine is also a metabolite of the antihypertensive drug methyldopa and plays a role in its pharmacology and effects.
Pharmacology
Pharmacokinetics
Corbadrine is metabolized primarily by catechol O-methyltransferase.Chemistry
Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or -3,4-dihydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.Analogues of corbadrine include α-methyldopamine, dioxifedrine, dioxethedrin, and hydroxyamphetamine.