SH 100 begins at an intersection with Main Street and the southern part of County [Road 36 (Baca County, Colorado)|County Road 36] in the central part of Vilas. From its southern terminus, SH 100 heads north to crossPine Street and connect with the east end of WestCedar Street before leaving the residential part of town. Continuing north SH 100 passes through agricultural area before reaching its northern terminus at an intersection with US 160 and the northern part of CR 36, near the northern edge of town.