Closed-loop all-optical interrogation of neural circuits in vivo
Closed-loop all-optical interrogation of neural circuits in vivo is a scholarly work by Zihui Zhang, Lloyd E. Russell, Adam Packer, Oliver M Gauld, and Michael Hausser, published in 2018 in ''Nature Methods''. The main subjects of the publication include stimulation, optogenetics, in vivo, neuroscience, electronic circuit, computer science, Closed loop, two-photon excitation microscope, Premovement neuronal activity, biological neural network, G protein-coupled recepteishon, and neurotransmission. The authors rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' during behavior.