Charles begun teaching at St. Mary's School at Konongo from 1934 to 1937. He spent the next six years working at the Konongo mines. He later joined C. F. A. O. and became its employee president in 1944. In 1949 he was appointed chairman of Asante Kotoko S.C. and served in that capacity until 1953. He was a member of a two-man delegation sent to Puerto Rico for the inaugural ceremony of President Luis Muñoz Marín. On 23 July 1956 he was appointed ministerial secretary to the Ministry of Education. In 1957 he was elevated to the post of Regional Commissioner of the Ashanti Region. In 1960 he was appointed Minister for Defence. He served in this position until 1961.
Personal life
De Graft-Dickson's hobbies included gardening and motoring. He died on 19 November 1997.