Charles Sprague

• Charles Sprague , American poet
• Charles James Sprague, American botanist
• Charles Sprague Smith, activist and founder of the People's Institute during the Progressive era
• Charles A. Sprague, Governor of Oregon, 1939–1943
• Charles Ezra Sprague, American accountant
• Charles F. Sprague, U.S. Representative from Massachusetts
• Charlie Sprague, American baseball player