Charles Middleton

• Charles Middleton, 2nd Earl of Middleton, Scottish and English politician
• Charles Middleton, 1st Baron Barham, British aristocrat, First Lord of the Admiralty
• Charles Middleton , English cricketer
• Charles Middleton , known for his portrayal of Ming the Merciless
• Charlie Middleton , English footballer
• Charles R. Middleton, president of Roosevelt University from 2002 to 2015
• Charles G. Middleton, chief of the Savannah Fire Department until 2018