Carbromal


Carbromal is a hypnotic/sedative originally synthesized in 1909 by Bayer and subsequently marketed as Adalin. The drug was later sold by Parke-Davis in combination with pentobarbital, under the name Carbrital. As of 2015, it was still used in Hungary in combination with aminophenazone under the name Demalgon.

Synthesis

Diethylmalonic acid is decarboxylated to 2-ethylvaleric acid . The Hell-Volhard-Zelinsky reaction converts this to 2-bromo-2-ethylbutyryl bromide . Reaction with urea with affords carbromal.