CREB3L1

CAMP responsive element binding protein 3 like 1, also known as OASIS, is a responsive [element binding protein] that in humans is encoded by the CREB3L1 gene.

Function

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum. However, upon stress to the ER, the encoded protein is cleaved, and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. .

Implications in Disease

Pathogenic variants in CREB3L1 have been linked to Osteogenesis Imperfecta.